Connexons for protein labeling and application of connexons in biological medicines

The invention provides a connexon used for protein labeling and application of the connexon in biological medicine, and particularly relates to a photoinduced o-nitrobenzyl alcohol connexon shown in a general formula (I) and application of the photoinduced o-nitrobenzyl alcohol connexon. The photo-induced o-nitrobenzyl alcohol linker developed by the invention can specifically mark protein side chain lysine, and then an affinity marker, a fluorescent substance, an active drug and the like are specifically coupled into biomacromolecules such as protein and an antibody, so that novel protein drugs and antibody drug ADC drugs, biological diagnostic reagents, biological diagnostic reagents and the like are developed. And a direct way is provided for design and development of the imaging probe and the like. 本发明提供了一类连接子用于蛋白质标记及其在生物药中的应用，特别涉及一种通式(I)所示光诱导的邻硝基苄醇连接子和用途。本发明开发的光诱导的邻硝基苄醇连接子能够对蛋白质侧链赖氨酸进行特异性标记，再将亲和标记物、荧光物质及活性药物等特异性偶联到蛋白质及抗体等生物大分子中，从而发展新型的蛋白质药物及抗体药物ADC药物，生物诊断试剂，成像探针等设计与开发提供了直接途径。