Preparation method of gelatin sponge microspheres

The invention discloses a preparation method of gelatin sponge microspheres, and belongs to the technical field of biological medicines and high polymer materials, and the preparation method comprises the following steps: a, preparing a dispersed phase solution; b, preparing a continuous phase solut...

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Hauptverfasser: REN XIN, CHU LIANGYIN, CAI QUANWEI, FENG XU, HUANG MIN, ZHANG CHUAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention discloses a preparation method of gelatin sponge microspheres, and belongs to the technical field of biological medicines and high polymer materials, and the preparation method comprises the following steps: a, preparing a dispersed phase solution; b, preparing a continuous phase solution; c, preparing a cross-linking solution; d, respectively injecting the dispersed phase solution in the step a and the continuous phase solution in the step b into a microfluidic device, and preparing gelatin liquid drops with expected specifications by controlling the flow rates of the dispersed phase and the continuous phase; e, cross-linking the gelatin liquid drops obtained in the step d with the cross-linking solution obtained in the step c to obtain a gelatin sponge microsphere crude product; and f, cleaning the gelatin sponge microsphere crude product in the step e to obtain the gelatin sponge microspheres. The method solves the problems that the gelatin sponge microspheres prepared in the prior art need t