Application of PCBP1 to generation of induced pluripotent stem cells and inhibition of tumorigenesis

The present disclosure provides compositions and methods for generating induced pluripotent stem cells (iPSCs) without inducing cancer or neogenesis using gene therapy. The methods disclosed herein use plasmids and vectors containing transcription factors and an anti-cancer gene, such as PCBP1 that inhibits the expression of cancer biomarkers and concomitant neogenesis. 本公开提供了使用基因疗法产生诱导多能干细胞(iPSC)而不诱导癌症或肿瘤发生的组合物和方法。本文公开的方法使用含有转录因子和抗癌基因如PCBP1的质粒和载体，所述PCBP1抑制癌症生物标记物的表达和伴随的肿瘤发生。