ANTIBODIES BINDING TO NKG2D

The present invention relates generally to antibodies that bind to NKG2D, including multispecific antigen binding molecules, e.g., for activating T cells and/or NK cells. In addition, the invention relates to polynucleotides encoding such antibodies, as well as vectors and host cells comprising such...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HOSS RALF, KLEIN CHRISTIAN, WALDHAUSER ISABELLE, GEORGES GUY, UMANA PABLO, DENGL STEFAN
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The present invention relates generally to antibodies that bind to NKG2D, including multispecific antigen binding molecules, e.g., for activating T cells and/or NK cells. In addition, the invention relates to polynucleotides encoding such antibodies, as well as vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing said antibodies, and to methods of using said antibodies for the treatment of disease. 本发明总体上涉及与NKG2D结合的抗体,包括多特异性抗原结合分子,例如用于活化T细胞和/或NK细胞。此外,本发明涉及编码此类抗体的多核苷酸,以及包含此类多核苷酸的载体和宿主细胞。本发明进一步涉及用于生产所述抗体的方法,以及涉及将所述抗体用于治疗疾病的方法。