Novel coronavirus neutralizing antibody and preparation method and application thereof

The invention relates to the technical field of biological medicines, and discloses a neutralizing antibody of a new coronavirus as well as a variant and application thereof. In a phage display antibody library, a plurality of strains of antibodies are obtained by screening through a phage panning technology, and the antibodies can be specifically combined with RBD structural domains on S proteins of various new coronaviruses, so that the combination of the S proteins and human ACE2 proteins is inhibited. The neutralizing antibody disclosed by the invention is high in affinity and strong in broad spectrum, can inhibit infection of the new coronavirus to human cells, plays a role in neutralizing virus toxicity, can be used for preparing medicines for preventing and treating new coronavirus diseases, can be used for preparing new coronavirus detection products and the like, and has a wide application prospect. 本发明涉及生物医药技术领域，公开了一种新冠病毒的中和性抗体及其变体和应用。本发明从噬菌体展示抗体文库中，通过噬菌体淘选技术筛选获得了多株抗体，其能够特异性地与多种新冠病毒的S蛋白上的RBD结构域结合，从而