Naringenin derivative and application thereof

The naringenin derivative is characterized in that the naringenin derivative is a compound with a structural formula shown in a formula I. R1, R2 and R3 are H, CH3, CH2F, CHF2, CF3, straight-chain alkane with the carbon atom number of 1-5, ester group, silyl ether, trifluoroalkane or polyfluoroalkane with the carbon atom number of 1-5, and straight-chain terminal alkyne alkane with the carbon atom number of 1-6, n is equal to 1, 2, 3, 4 or 5, m is equal to 1, 2, 3, 4, 5 or 6, and n is equal to 1, 2, 3, 4, 5 or 6. The naringenin derivative can be used for preparing drugs for treating chemotherapy pain, inhibitors for activating spinal glial cells induced by chemotherapy pain and drugs for relieving inflammatory pain and neuropathic pain, and has the advantage of remarkable analgesic effect. 本发明公开了柚皮素衍生物及其用途，特点是具有I式所示结构式的化合物，其中，R1、R2和R3均为H、CH3、CH2F、CHF2、CF3、碳原子位数为1-5的直链烷烃、酯基、硅醚、碳原子位数为1-5的三氟或多氟代烷烃，碳原子位数为1-6的直链端炔烷烃，n=1，2，3，4或5，m=1，2，3，4、5或6，该柚皮素衍生物在制备治疗化疗痛药物、化疗痛诱发的脊髓胶质细胞激活抑制剂和减轻炎性疼痛和神经病理性疼痛药物方面的用途，优点是具有显著镇痛效果。