Gastric cancer molecular targeting nucleic acid drug
The present invention provides a nucleic acid drug which inhibits the expression of SYT13 by using an antisense nucleic acid and has a better effect than siRNA targeting gastric cancer peritoneal dissemination. Provided are: an antisense oligonucleotide which is composed of a base sequence substanti...
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| creator | KANDA MITSUO OBIKA SATOSHI KASAHARA YUYA |
| description | The present invention provides a nucleic acid drug which inhibits the expression of SYT13 by using an antisense nucleic acid and has a better effect than siRNA targeting gastric cancer peritoneal dissemination. Provided are: an antisense oligonucleotide which is composed of a base sequence substantially complementary to a base sequence in a specific region of human SYT13mRNA, and which is capable of inhibiting the expression of human SYT13mRNA; and a pharmaceutical composition containing the antisense oligonucleotide.
本发明提供一种通过使用反义核酸抑制SYT13的表达而与以胃癌腹膜播散为靶标的siRNA相比的效果更加优异的核酸药物。本发明提供一种反义寡核苷酸、及含有该反义寡核苷酸的药物组合物，所述反义寡核苷酸由与人SYT13mRNA的特定区的碱基序列实质上互补的碱基序列构成，能够抑制人SYT13mRNA表达。 |
| format | Patent |
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本发明提供一种通过使用反义核酸抑制SYT13的表达而与以胃癌腹膜播散为靶标的siRNA相比的效果更加优异的核酸药物。本发明提供一种反义寡核苷酸、及含有该反义寡核苷酸的药物组合物，所述反义寡核苷酸由与人SYT13mRNA的特定区的碱基序列实质上互补的碱基序列构成，能够抑制人SYT13mRNA表达。</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220412&DB=EPODOC&CC=CN&NR=114341355A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220412&DB=EPODOC&CC=CN&NR=114341355A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KANDA MITSUO</creatorcontrib><creatorcontrib>OBIKA SATOSHI</creatorcontrib><creatorcontrib>KASAHARA YUYA</creatorcontrib><title>Gastric cancer molecular targeting nucleic acid drug</title><description>The present invention provides a nucleic acid drug which inhibits the expression of SYT13 by using an antisense nucleic acid and has a better effect than siRNA targeting gastric cancer peritoneal dissemination. Provided are: an antisense oligonucleotide which is composed of a base sequence substantially complementary to a base sequence in a specific region of human SYT13mRNA, and which is capable of inhibiting the expression of human SYT13mRNA; and a pharmaceutical composition containing the antisense oligonucleotide.
本发明提供一种通过使用反义核酸抑制SYT13的表达而与以胃癌腹膜播散为靶标的siRNA相比的效果更加优异的核酸药物。本发明提供一种反义寡核苷酸、及含有该反义寡核苷酸的药物组合物，所述反义寡核苷酸由与人SYT13mRNA的特定区的碱基序列实质上互补的碱基序列构成，能够抑制人SYT13mRNA表达。</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBxTywuKcpMVkhOzEtOLVLIzc9JTS7NSSxSKEksSk8tycxLV8grTc5JBSpJTM5MUUgpKk3nYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhibGJobGpqaOxsSoAQAxXiy5</recordid><startdate>20220412</startdate><enddate>20220412</enddate><creator>KANDA MITSUO</creator><creator>OBIKA SATOSHI</creator><creator>KASAHARA YUYA</creator><scope>EVB</scope></search><sort><creationdate>20220412</creationdate><title>Gastric cancer molecular targeting nucleic acid drug</title><author>KANDA MITSUO ; OBIKA SATOSHI ; KASAHARA YUYA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114341355A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KANDA MITSUO</creatorcontrib><creatorcontrib>OBIKA SATOSHI</creatorcontrib><creatorcontrib>KASAHARA YUYA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KANDA MITSUO</au><au>OBIKA SATOSHI</au><au>KASAHARA YUYA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Gastric cancer molecular targeting nucleic acid drug</title><date>2022-04-12</date><risdate>2022</risdate><abstract>The present invention provides a nucleic acid drug which inhibits the expression of SYT13 by using an antisense nucleic acid and has a better effect than siRNA targeting gastric cancer peritoneal dissemination. Provided are: an antisense oligonucleotide which is composed of a base sequence substantially complementary to a base sequence in a specific region of human SYT13mRNA, and which is capable of inhibiting the expression of human SYT13mRNA; and a pharmaceutical composition containing the antisense oligonucleotide.
本发明提供一种通过使用反义核酸抑制SYT13的表达而与以胃癌腹膜播散为靶标的siRNA相比的效果更加优异的核酸药物。本发明提供一种反义寡核苷酸、及含有该反义寡核苷酸的药物组合物，所述反义寡核苷酸由与人SYT13mRNA的特定区的碱基序列实质上互补的碱基序列构成，能够抑制人SYT13mRNA表达。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Gastric cancer molecular targeting nucleic acid drug |
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