Gastric cancer molecular targeting nucleic acid drug

The present invention provides a nucleic acid drug which inhibits the expression of SYT13 by using an antisense nucleic acid and has a better effect than siRNA targeting gastric cancer peritoneal dissemination. Provided are: an antisense oligonucleotide which is composed of a base sequence substantially complementary to a base sequence in a specific region of human SYT13mRNA, and which is capable of inhibiting the expression of human SYT13mRNA; and a pharmaceutical composition containing the antisense oligonucleotide. 本发明提供一种通过使用反义核酸抑制SYT13的表达而与以胃癌腹膜播散为靶标的siRNA相比的效果更加优异的核酸药物。本发明提供一种反义寡核苷酸、及含有该反义寡核苷酸的药物组合物，所述反义寡核苷酸由与人SYT13mRNA的特定区的碱基序列实质上互补的碱基序列构成，能够抑制人SYT13mRNA表达。