Antisense oligonucleotide therapy for cancer

The invention relates to a separated or purified antisense oligomer, which is used for modifying precursor mRNA splicing in a LIN28B gene transcript or a part of the LIN28B gene transcript. The present invention relates to isolated or purified antisense oligomers having a modified skeletal structure...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	VERDU RAVI N, CHEN SHIHEMN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to a separated or purified antisense oligomer, which is used for modifying precursor mRNA splicing in a LIN28B gene transcript or a part of the LIN28B gene transcript. The present invention relates to isolated or purified antisense oligomers having a modified skeletal structure and a sequence having at least 95% sequence identity with isolated or purified antisense oligomers having a modified skeletal structure for modifying precursor mRNA splicing, and/or inducing RNase H, and/or translation blocking in a LIN28B gene transcript or part thereof. 分离或纯化的反义寡聚体，其用于修饰LIN28B基因转录本或其部分中的前体mRNA剪接，其具有修饰的骨架结构和与具有修饰的骨架结构以用于在LIN28B基因转录本或其部分中修饰前体mRNA剪接、和/或诱导RNase H、和/或翻译阻断的分离或纯化的反义寡聚体具有至少95％序列同一性的序列。