Synthetic method of plecanatide

The invention discloses a synthetic method of plecanatide, and belongs to the technical field of polypeptide synthesis. The method comprises the following steps: sequentially coupling 16-12th amino acids on solid-phase synthesis WANG resin according to an Fmoc solid-phase synthesis strategy, sequentially coupling 9-4th amino acids on the 16-12th amino acids according to the Fmoc solid-phase synthesis strategy, cracking the resin by using a cracking reagent, carrying out diethyl ether sedimentation to obtain plecanatide linear peptide, carrying out H2O2 oxidation reaction to form a disulfide bond between 4th Cys and 12th Cys, and adding I2 for oxidation reaction to obtain plecanatide linear peptide. Forming a disulfide bond between the Cys at the 7 site and the Cys at the 15 site, and purifying by a chromatographic column to obtain plecanatide. The synthesis rate is increased, the purity of crude peptide is improved, the material cost is reduced, and industrial production is facilitated. 本发明公开了一种普卡那肽的合成方法，属多肽合