URAT1 inhibitor as well as preparation method and application thereof
The invention discloses a URAT1 inhibitor, a preparation method thereof and an application of the URAT1 inhibitor in preparation of a medicine for inhibiting URAT1, the structural formula of the URAT1 inhibitor is shown as a formula I. The invention provides a compound shown as the formula I or a ta...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a URAT1 inhibitor, a preparation method thereof and an application of the URAT1 inhibitor in preparation of a medicine for inhibiting URAT1, the structural formula of the URAT1 inhibitor is shown as a formula I. The invention provides a compound shown as the formula I or a tautomer, a mesomer, a raceme, an enantiomer, a diastereoisomer and a mixture form of the compound, and pharmaceutically acceptable salts of the compound or the tautomer, the mesomer, the raceme, the enantiomer, the diastereoisomer and the mixture form. The compound disclosed by the invention is a selective uric acid reuptake inhibitor, can treat hyperuricemia and gout by promoting excretion of uric acid from a body and reducing serum uric acid, has a very good inhibition effect on urate transporter 1, and shows the effects of efficiently reducing uric acid and being low in toxicity in animal bodies.
本发明公开了一类URAT1抑制剂及其制备方法与在制备抑制URAT1的药物中的用途,所述的URAT1抑制剂结构式如式I所示,本发明提供的式I所示的化合物或其互变异构体、内消旋体、外消旋体、对映异构体、非对映异构体及其混合物形式,及其药学上 |
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