Preparation of chiral separation column for tetramisole resolution

The invention discloses a preparation method of a chiral separation column for tetramisole resolution, which comprises the following steps: (1) material proportioning: proportioning levamisole hydrochloride and dextro-imidazole hydrochloride which are equal in quantity, and then carrying out experimental use, and (2) mixing reaction: by utilizing tetramisole hydrochloride and a chiral substrate, carrying out a reaction for 2-3 hours, and carrying out a reaction for 2-3 hours to obtain the chiral separation column for tetramisole resolution. The preparation method comprises the following steps: putting an L, L-glutamyl-p-toluenesulfonamide material into a reaction kettle, mixing, cooling the equipment, and reacting at low temperature. According to the preparation of the chiral separation column for tetraimidazole resolution, in the use process, a main exchange group of strong acid type ion exchange resin is cation exchange resin of substituted benzenesulfonic acid (p-C6H4-SO3H), and the cation exchange resin c