Mesoporous nano-carrier for transporting antibacterial peptide

The invention relates to a mesoporous nano-drug carrier. Silicon dioxide, calcium carbonate, calcium phosphate and the like with good biocompatibility are selected as materials to realize loading and oral administration of antibacterial peptides. A mesoporous nano-carrier for transporting antibacter...

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Bibliographische Detailangaben
Hauptverfasser: YU LIYUN, WANG YU, LIU JIAYING, YE LINGTAO, LI YULIN, WEI FANGTONG, SUN YAN, XIE YONGCHAO
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to a mesoporous nano-drug carrier. Silicon dioxide, calcium carbonate, calcium phosphate and the like with good biocompatibility are selected as materials to realize loading and oral administration of antibacterial peptides. A mesoporous nano-carrier for transporting antibacterial peptide is designed and synthesized, the surface of the mesoporous nano-carrier and the surfaces of mesoporous channels are designed into hydrophobic structures, and the antibacterial peptide is loaded in modes of adsorption, access control and the like. A multifunctional nano biological composite carrier with targeting/visualization/good biocompatibility is synthesized by modifying the surfaces of nano particles with a targeting agent and a fluorophore, and the antibacterial peptide can be released in intestinal tracts or colons by applying methods such as targeting and access control environment condition release and pressure release. 本发明涉及一种介孔纳米药物载体,材料选择具有良好生物相容性的二氧化硅、碳酸钙、磷酸钙等实现对抗菌肽的负载和口服给药。本发明设计合成了转运抗菌肽的介孔纳