TPGS micelle oral liquid containing gabapentin compound and preparation method of TPGS micelle oral liquid

The invention relates to TPGS micelle oral liquid containing a gabapentin compound. The gabapentin compound is prepared from gabapentin and fatty acid or prepared from gabapentin, fatty acid salt and hydrochloric acid. The prepared TPGS micelle oral liquid containing the gabapentin compound can effectively reduce generation of condensation compound lactam in gabapentin molecules, improves drug stability, masks bitter taste of gabapentin, and improves compliance of patients. 本发明涉及一种含有加巴喷丁复合物的TPGS胶束口服液，其中加巴喷丁复合物是由加巴喷丁和脂肪酸或者由加巴喷丁、脂肪酸盐和盐酸来制备。所制备的含有加巴喷丁复合物的TPGS胶束口服液可有效地降低加巴喷丁分子内缩合物内酰胺的生成，提高了药物稳定性，且掩盖了加巴喷丁的苦味，提高了患者的顺应性。