Organ chip and application thereof

The invention belongs to the technical field of tissue engineering, and particularly relates to an organ chip and application thereof. The organ chip comprises a first functional layer, a second functional layer, a third functional layer and a fourth functional layer, the first functional layer, the second functional layer, the third functional layer and the fourth functional layer are sequentially combined from top to bottom. The invention provides a method for establishing a model which is based on an organ chip and can be used for simulating transmission and action of viruses in a human body after the viruses enter the human body through air, and the structure and the function of a normal or diseased organ level are simulated by combining simulation of in-vivo circulating strain (i.e., wriggle-like movement) and the like. And the transmission and action of the virus in the human body after the virus enters the human body can be better simulated. 本申请属于组织工程技术领域，尤其涉及一种器官芯片及其应用。本申请第一方面提供了一种器官芯片包括：第一功能层、第二功能层、第