Micro-screening device, method and product
Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high throughput analysis of cell and protein products using a range of fluorescence assays, including binding affinity measurements and time-resolved enzyme as...
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| creator | LAM SIVETTE DIMOV IVAN COCHRAN JENNIFER R BAER THOMAS M ALFORD SEAN CHRISTOPHER CHEN BICHENG KANNAN ARVIND |
| description | Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high throughput analysis of cell and protein products using a range of fluorescence assays, including binding affinity measurements and time-resolved enzyme assays. The invention relates to laser-based microcavity content extraction. In one aspect, the disclosure relates to a system comprising an array of a plurality of different cavities, the cavities comprising an open first end and an open second end; an electromagnetic radiation absorbing material associated with the cavity; and a pulsed diode laser configured to deliver electromagnetic radiation to the electromagnetic radiation absorbing material. In various embodiments of the system, the cavity may be a molten capillary.
用于生物变体种群的定量生物化学和生物物理分析的微腔阵列和方法。实例包括细胞和蛋白质产物的高通量分析使用一系列荧光测定，包括结合亲和力测量和时间分辨酶测定。基于激光的微腔内容物提取。在一个方面，本公开涉及一种系统，包括多个不同腔体的阵列的，该腔体包括开放的第一端和开放的第二端；与腔体相关联的电磁辐射吸收材料；以及被配置为将电磁辐射传送到电磁辐射吸收材料的脉冲二极管激光器。在该系统的各种实施方式 |
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用于生物变体种群的定量生物化学和生物物理分析的微腔阵列和方法。实例包括细胞和蛋白质产物的高通量分析使用一系列荧光测定，包括结合亲和力测量和时间分辨酶测定。基于激光的微腔内容物提取。在一个方面，本公开涉及一种系统，包括多个不同腔体的阵列的，该腔体包括开放的第一端和开放的第二端；与腔体相关联的电磁辐射吸收材料；以及被配置为将电磁辐射传送到电磁辐射吸收材料的脉冲二极管激光器。在该系统的各种实施方式</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PHYSICS ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220405&DB=EPODOC&CC=CN&NR=114277081A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220405&DB=EPODOC&CC=CN&NR=114277081A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAM SIVETTE</creatorcontrib><creatorcontrib>DIMOV IVAN</creatorcontrib><creatorcontrib>COCHRAN JENNIFER R</creatorcontrib><creatorcontrib>BAER THOMAS M</creatorcontrib><creatorcontrib>ALFORD SEAN CHRISTOPHER</creatorcontrib><creatorcontrib>CHEN BICHENG</creatorcontrib><creatorcontrib>KANNAN ARVIND</creatorcontrib><title>Micro-screening device, method and product</title><description>Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high throughput analysis of cell and protein products using a range of fluorescence assays, including binding affinity measurements and time-resolved enzyme assays. The invention relates to laser-based microcavity content extraction. In one aspect, the disclosure relates to a system comprising an array of a plurality of different cavities, the cavities comprising an open first end and an open second end; an electromagnetic radiation absorbing material associated with the cavity; and a pulsed diode laser configured to deliver electromagnetic radiation to the electromagnetic radiation absorbing material. In various embodiments of the system, the cavity may be a molten capillary.
用于生物变体种群的定量生物化学和生物物理分析的微腔阵列和方法。实例包括细胞和蛋白质产物的高通量分析使用一系列荧光测定，包括结合亲和力测量和时间分辨酶测定。基于激光的微腔内容物提取。在一个方面，本公开涉及一种系统，包括多个不同腔体的阵列的，该腔体包括开放的第一端和开放的第二端；与腔体相关联的电磁辐射吸收材料；以及被配置为将电磁辐射传送到电磁辐射吸收材料的脉冲二极管激光器。在该系统的各种实施方式</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PHYSICS</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDyzUwuytctTi5KTc3LzEtXSEkty0xO1VHITS3JyE9RSMxLUSgoyk8pTS7hYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxzn6GhiZG5uYGFoaOxsSoAQAViCjF</recordid><startdate>20220405</startdate><enddate>20220405</enddate><creator>LAM SIVETTE</creator><creator>DIMOV IVAN</creator><creator>COCHRAN JENNIFER R</creator><creator>BAER THOMAS M</creator><creator>ALFORD SEAN CHRISTOPHER</creator><creator>CHEN BICHENG</creator><creator>KANNAN ARVIND</creator><scope>EVB</scope></search><sort><creationdate>20220405</creationdate><title>Micro-screening device, method and product</title><author>LAM SIVETTE ; DIMOV IVAN ; COCHRAN JENNIFER R ; BAER THOMAS M ; ALFORD SEAN CHRISTOPHER ; CHEN BICHENG ; KANNAN ARVIND</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114277081A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PHYSICS</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>LAM SIVETTE</creatorcontrib><creatorcontrib>DIMOV IVAN</creatorcontrib><creatorcontrib>COCHRAN JENNIFER R</creatorcontrib><creatorcontrib>BAER THOMAS M</creatorcontrib><creatorcontrib>ALFORD SEAN CHRISTOPHER</creatorcontrib><creatorcontrib>CHEN BICHENG</creatorcontrib><creatorcontrib>KANNAN ARVIND</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAM SIVETTE</au><au>DIMOV IVAN</au><au>COCHRAN JENNIFER R</au><au>BAER THOMAS M</au><au>ALFORD SEAN CHRISTOPHER</au><au>CHEN BICHENG</au><au>KANNAN ARVIND</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Micro-screening device, method and product</title><date>2022-04-05</date><risdate>2022</risdate><abstract>Microcavity arrays and methods for quantitative biochemical and biophysical analysis of populations of biological variants. Examples include high throughput analysis of cell and protein products using a range of fluorescence assays, including binding affinity measurements and time-resolved enzyme assays. The invention relates to laser-based microcavity content extraction. In one aspect, the disclosure relates to a system comprising an array of a plurality of different cavities, the cavities comprising an open first end and an open second end; an electromagnetic radiation absorbing material associated with the cavity; and a pulsed diode laser configured to deliver electromagnetic radiation to the electromagnetic radiation absorbing material. In various embodiments of the system, the cavity may be a molten capillary.
用于生物变体种群的定量生物化学和生物物理分析的微腔阵列和方法。实例包括细胞和蛋白质产物的高通量分析使用一系列荧光测定，包括结合亲和力测量和时间分辨酶测定。基于激光的微腔内容物提取。在一个方面，本公开涉及一种系统，包括多个不同腔体的阵列的，该腔体包括开放的第一端和开放的第二端；与腔体相关联的电磁辐射吸收材料；以及被配置为将电磁辐射传送到电磁辐射吸收材料的脉冲二极管激光器。在该系统的各种实施方式</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE |
| title | Micro-screening device, method and product |
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