Nucleic acid-oriented nano-composite for target RNA degradation and preparation method thereof
The invention relates to a nano-composite for target RNA (Ribonucleic Acid) degradation guided by nucleic acid. The nano-composite comprises a recruitment group of ribonuclease RNase L and a recognition sequence of a specific mRNA (Messenger Ribonucleic Acid) target, the carrier of the nano-composit...
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| creator | LIU ZHAODI LI ZIGANG JIANG LEYING YIN FENG ZHANG YAPING |
| description | The invention relates to a nano-composite for target RNA (Ribonucleic Acid) degradation guided by nucleic acid. The nano-composite comprises a recruitment group of ribonuclease RNase L and a recognition sequence of a specific mRNA (Messenger Ribonucleic Acid) target, the carrier of the nano-composite is gold nanoparticles; a recruitment group of RNase L and a recognition sequence of a specific mRNA target are randomly modified on a carrier through Au-S coordinate bonds. After an mRNA recognition sequence on the compound is complementarily paired with a specific mRNA target, the whole nanostructure is pulled to be near mRNA, then an RNase L recruitment group on the compound randomly recruits a monomer of RNase L at a proper spatial position to form a dimer to induce RNase L activation, and finally, degradation of the target mRNA is realized. The two active groups are randomly fixed on the gold nano-carrier and do not interfere with each other, and recognition sequences of mRNA can be quickly replaced according |
| format | Patent |
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| language | chi ; eng |
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| subjects | HUMAN NECESSITIES HYGIENE MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES MEDICAL OR VETERINARY SCIENCE NANOTECHNOLOGY PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES TRANSPORTING |
| title | Nucleic acid-oriented nano-composite for target RNA degradation and preparation method thereof |
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