Tiotropium bromide inhalation microsphere, preparation method thereof and inhalation type preparation

The invention relates to the technical field of medicine microspheres, in particular to tiotropium bromide inhalation microspheres, a preparation method thereof and an inhalation type preparation. The preparation method of the tiotropium bromide inhalation microspheres comprises the steps that a carrier, a tiotropium bromide raw material and acetonitrile are mixed and then subjected to spray drying, and the carrier comprises a polylactic acid-glycolic acid copolymer. The tiotropium bromide inhalation microsphere prepared by the preparation method not only can continuously release tiotropium bromide and has higher drug loading capacity and encapsulation efficiency, but also is good in balling property and uniform in particle size. 本发明涉及药物微球技术领域，具体而言，涉及噻托溴铵吸入微球及其制备方法和吸入式制剂。噻托溴铵吸入微球的制备方法包括：将载体、噻托溴铵原料和乙腈混合后进行喷雾干燥，其中，所述载体包括聚乳酸-羟基乙酸共聚物。该制备方法制备得到的噻托溴铵吸入微球不仅可以持续释放噻托溴铵，有较高载药量和包封率，同时，该噻托溴铵吸入微球成球性好，且粒度均一。