Synthesis method of rutaecarpin

The invention discloses a synthetic method of rutaecarpin, and relates to the technical field of organic synthesis, tryptamine and isatoic anhydride are adopted as raw materials, N-(2-aminobenzoyl) tryptamine is prepared by condensation reaction in a solvent, then 7, 8, 13b, 14-tetrahydroindolo [2 ', 3': 3, 4] pyrido [2, 1-b] quinazoline-5 (7H)-one is prepared by reaction of N-(2-aminobenzoyl) tryptamine and a cyclization reagent under the action of a catalyst, and the 7, 8, 13b, 14-tetrahydroindolo [2 ', 3': 3, 4] pyrido [2, 1-b] quinazoline-5 (7H)-one is prepared by condensation reaction. And finally, reacting with an oxidizing reagent to obtain rutaecarpin. Tryptamine and isatoic anhydride are adopted as raw materials, the reaction condition is mild, the yield is high, the raw materials are easy to obtain, the cost is low, dangerous chemicals such as phosphorus oxychloride and triphosgene are not used, the safety is improved, and the method is suitable for industrial production. 本发明公开了一种吴茱萸次碱的合成方法，涉及有机合成技术