Low-molecular-weight cationized hyaluronate as well as preparation method and application thereof

The invention discloses low-molecular-weight cationized hyaluronate as well as a preparation method and application thereof, and belongs to the technical field of biochemical engineering. The preparation method comprises the following steps: taking low-molecular hyaluronate with the average molecular weight of 800-1200Da and glycidyl trimethyl ammonium chloride as raw materials, uniformly stirring in an anhydrous alcohol solvent, and coupling under the action of a phase transfer catalyst and anhydrous alkali to obtain the cationized hyaluronic acid/salt. The cationic permeabilized hyaluronic acid/salt obtained by the invention has high moisture retention, strong hydrophilicity, good adsorbability and affinity, the preparation conditions are simple, the operation is easy, and the product can be obtained by spray drying. When being applied to hair improving products and cleaning cosmetics, the moisturizing composition can be directly adsorbed on the surfaces of hair and skin to keep the hair and skin in a moist