Fusion protein and recombinant virion for displaying novel crown S protein and application of fusion protein and recombinant virion

The invention provides a fusion protein and a recombinant virion showing a new crown S protein and application thereof, and belongs to the technical field of biological products. The invention provides a fusion gene and a fusion protein for expressing a novel crown S protein. The fusion gene or the fusion protein comprises an extracellular domain sequence of the novel crown S protein and transmembrane domain and intracellular domain sequences of avian paramyxoviridae F protein. Meanwhile, the recombinant NDV virus containing the sequence has a relatively strong capability of neutralizing an antibody. Therefore, the fusion gene or protein generated by fusing the extracellular domain coding sequence of the S protein and the transmembrane domain and intracellular domain coding sequences of the F protein of the APMV viridae virus (except NDV) has huge potential of becoming an excellent new crown vaccine candidate antigen. 本发明提供了一种展示新冠S蛋白的融合蛋白和重组病毒粒子及其应用，本发明属于生物制品技术领域。本发明提供了一种表达新冠S蛋白的融合基因及融合蛋白，该融合基因或融合蛋白包含新冠S蛋白的胞外