Preparation method of N alkyl substituted pyrrolidone compound

The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method of an N-alkyl substituted pyrrolidone compound, which comprises the following steps: (1) adding an N-alkyl substituted pyrrole acetyl compound, alcohol and potassium tert-butoxide into...

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Hauptverfasser: LAI MIAO, ZHAO QIANRUI, SU FANGYAO, ZHAO MINGQIN, JI XIAOMING, HU JINGYI
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention belongs to the technical field of organic synthesis, and particularly discloses a preparation method of an N-alkyl substituted pyrrolidone compound, which comprises the following steps: (1) adding an N-alkyl substituted pyrrole acetyl compound, alcohol and potassium tert-butoxide into an organic solvent for stirring reaction, and then cooling to room temperature to obtain a reaction solution; and (2) concentrating, separating and purifying the reaction liquid obtained in the step (1). The simple and effective method for preparing the N-alkyl substituted pyrrolidone compound under the condition of no metal and no ligand is realized, the N-alkyl substituted pyrrole acetyl compound and alcohol which are economical and easy to obtain are used as raw materials, and under the action of alkali, the raw materials are stirred in an organic solvent to generate an alkylation reaction to generate the corresponding N-alkyl substituted pyrrolidone compound, so that the N-alkyl substituted pyrrolidone compound