Reticulocyte simulant, preparation method thereof and reticulocyte quality control substance

The invention relates to the technical field of biological detection, and particularly discloses a reticulocyte simulant, a preparation method thereof and a reticulocyte quality control substance, and the method comprises the following steps: obtaining purified erythrocytes and a magnetic tannin composite material; destroying at least part of cell membranes of the purified red blood cells; loading the magnetic tannin composite material on the purified RNA fragment of the red blood cell; and fixing the purified red blood cells loaded with the magnetic tannin composite material to obtain the reticulocyte simulant. Through the mode, nucleic acid or similar biological polymers do not need to be used, the steps are simple, processing is convenient, and a novel preparation method is provided for the reticulocyte simulant. 本申请涉及生物检测技术领域，具体公开了一种网织红细胞模拟物及其制备方法、网织红细胞质控物，该方法包括：获取纯化后的红细胞和磁性单宁复合材料；破坏纯化后的红细胞的至少部分细胞膜；将磁性单宁复合材料加载于纯化后的红细胞的RNA片段上；对加载有磁性单宁复合材料的纯化后的红细胞进行固定处理，得到网织红细胞模拟物。通过上述方式，本申请不必使用核酸或类似生物多聚物，步骤简单，便于加工，为网织红细胞模拟