Tea extract EGCG prodrug based on quinone oxidoreductase as well as preparation method and application of tea extract EGCG prodrug

The invention discloses a preparation method and application of a quinone oxidoreductase tea extract EGCG prodrug, and the preparation method of the quinone oxidoreductase tea extract EGCG prodrug comprises the following steps: (1) synthesizing a compound 1; (2) synthesizing a compound 2; (3) synthesizing a compound 3; and (4) synthesizing a compound 4 to prepare the brown solid quinone oxidoreductase tea extract EGCG prodrug. According to the invention, EGCG extracted from tea leaves is subjected to site modification, such that an EGCG prodrug with specific response to NQO1 is obtained. The prodrug shows remarkable in-situ detection property and antitumor activity, and meanwhile, the EGCG is extracted from tea leaves, so that the EGCG has relatively low toxic and side effects and better water solubility, and is more beneficial to absorption and metabolism of human tissues. 本发明公开了醌氧化还原酶茶叶提取物EGCG前药的制备方法及其应用，本发明的醌氧化还原酶茶叶提取物EGCG前药的制备方法，包括如下步骤：(1)化合物1的合成；(2)化合物2的合成；(3)化合物3的合成；(4)化合物4的合成，制得褐色固体醌氧化还原酶茶叶提取物EGCG前药。本发