Intermediate for preparing procaterol hydrochloride and preparation method thereof

The invention belongs to the technical field of medicine synthesis, and particularly relates to an intermediate capable of being used for preparing procaterol hydrochloride and a preparation method of the intermediate. The invention provides an intermediate. The structural formula of the intermediat...

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Bibliographische Detailangaben
Hauptverfasser: YU LELE, SUI YUMIN, LIU ZHIGUO, YANG MENGDIE, WANG CHUNYAN
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention belongs to the technical field of medicine synthesis, and particularly relates to an intermediate capable of being used for preparing procaterol hydrochloride and a preparation method of the intermediate. The invention provides an intermediate. The structural formula of the intermediate is shown in the specification. According to the procaterol hydrochloride intermediate and the preparation method thereof, 8-butyryloxyquinolone is taken as a raw material, so that the use of a raw material 2-bromobutyryl chloride or 2-bromobutyryl bromide reagent which is unstable and causes more side reactions is avoided; the problems that the bromine bromination reaction conditions are harsh and difficult to control, the process stability and reproducibility are poor, and the use is inconvenient are solved. When the compound is used for preparing procaterol hydrochloride, the synthesis process is simple and easy to control, the efficiency is improved, and the compound is suitable for large-scale industrial prod