Drug sustained-release controllable polyether-ether-ketone implant and preparation method thereof

The invention discloses a drug sustained-release controllable polyether-ether-ketone implant and a preparation method thereof. The implant comprises a drug loading area and a solid area, the solid area comprises a first polyether-ether-ketone substrate, and the drug loading area comprises a second p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SHU ZIXING, YAN CHUNZE, SHI YUSHENG, SU JIN, CHEN ZHIYUAN, CHEN PENG, WANG HAOZE, WU SIQI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	The invention discloses a drug sustained-release controllable polyether-ether-ketone implant and a preparation method thereof. The implant comprises a drug loading area and a solid area, the solid area comprises a first polyether-ether-ketone substrate, and the drug loading area comprises a second polyether-ether-ketone substrate, a drug loading medium and a drug or an active factor loaded on the second polyether-ether-ketone substrate through the drug loading medium; the second polyether-ether-ketone substrate is provided with mutually communicated concave holes smaller than or equal to 10 microns, and the strength of the first polyether-ether-ketone substrate meets the requirement that the implant keeps the original structure during use; the first polyether-ether-ketone substrate and the second polyether-ether-ketone substrate are obtained through selective laser sintering printing. The slow release rate and time of drugs or active factors are regulated and controlled by using different porosities, and the