Preparation method and application of mesalazine enema

The invention discloses an enema liquid containing mesalazine. The enema liquid is prepared from the following raw material medicines and auxiliary materials in parts by weight: 3.0 to 8.0 parts of mesalazine, 1.0 to 2.0 parts of xanthan gum, 20.0 to 44.0 parts of edetate disodium, 10.0 to 15.0 parts of sodium benzoate, 0.5 to 1.0 part of carbomer, 9.0 to 28.0 parts of a pH (Potential of Hydrogen) regulator and 1.0 to 4.0 parts of an antioxidant. The mesalazine-containing enema can be conveniently applied to patients unsuitable for swallowing, the dosage form directly acts on the rectum, the drug release is rapid, and the bioavailability is improved. 本发明公开了一种含美沙拉秦的灌肠液，是由以下重量份的原料药及辅料制成的：美沙拉秦3.0～8.0份，黄原胶1.0～2.0份，依地酸二钠20.0～44.0份,苯甲酸钠10.0～15.0份，卡波姆0.5～1.0份，pH调节剂9.0～28.0份，抗氧化剂1.0～4.0份。本发明含有美沙拉秦的灌肠液，可方便应用于不适合吞咽的患者，该剂型直接作用于直肠，药物释放迅速，提高了生物利用度。