Preparation method of brexpiprazole intermediate

The invention belongs to the technical field of medicine production, and particularly relates to a brexpiprazole intermediate preparation method, a synthetic route is as follows: substituent groups X at the first site and the fourth site of 1, 4-disubstituted butane are independently or respectively the same or different halogen elements and hydroxyl groups, and R is alkali metal ions, the raw materials are easy to obtain, the operation is easy, the method is green and environment-friendly, the industrialization is easy, and the method is suitable for industrial production. And the product yield and purity are high. 本发明属于医药生产技术领域，具体是涉及一种依匹哌唑中间体的制备方法，合成路线如下：1,4-二取代丁烷的1位和4位取代基X独立或分别为相同或不同的卤元素、羟基，所述R为碱金属离子，本发明原料易得，易于操作，绿色环保，易于工业化，产物收率和纯度较高。