Antigen peptide combination related to liver cancer driver gene mutation and application thereof

The invention discloses an antigen peptide combination related to liver cancer driver gene mutation. The liver cancer driver genes are NFE2L2, PREX2 and ZFHX3; the sequences of the antigen peptide combination are as shown in SEQ ID NO.7, SEQ ID NO.14 and SEQ ID NO.15; according to the application of the antigen peptide combination, the antigen peptide combination is used for inducing generation of specific cytotoxic T cell clone; the antigen peptide combination has high affinity with MHC I molecules on DC cells, can effectively stimulate and induce generation of specific cytotoxic T lymphocytes, can be used for immune clearance of tumor cells with driver gene mutation related to liver cancer, and has good treatment potential. 本发明公开了一种与肝癌驱动基因突变相关的抗原肽组合，肝癌驱动基因为NFE2L2、PREX2和ZFHX3；抗原肽组合的序列为SEQ ID NO.7、SEQ ID NO.14和SEQ ID NO.15；抗原肽组合的应用，将抗原肽组合用于诱导产生特异性细胞毒性T细胞克隆；抗原肽组合具有与DC细胞上MHC I分子高度的亲和力，并能有效地刺激、诱导产生特异性细胞毒性T淋巴细胞，可用于与肝癌相关驱动基因突变的肿瘤细胞的免疫清除，具备良好治疗潜力。