Monoclonal antibodies against beta chain region of human TRBV9

The present invention relates to monoclonal humanized antibodies or antigen-binding fragments thereof that specifically bind to the TRBV9 family of human T cell receptors. The invention also relates to nucleic acids encoding said antibodies or antigen-binding fragments thereof, expression vectors, m...

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Hauptverfasser:	MISORIN ALEKSEY KONSTANTINOVICH, NIEMANKIN TIMOTHY A, VLADIMIROVA, ANNA KONSTANTINOVNA, SEMELEVA MARIYA ALEKSANDROVNA, BRITANOVA OLGA VLADIMIROVNA, EVSTRATOVA, ANNA VLADIMIROVNA, ANIKHINA ARTEM VASILIEVICH, STAROVEROV DMITRY BORISOVICH, IVANOV ROMAN A, YAKOVLEV PAVEL ANDREEVICH, LUKYANOV SERGEY ANATOLIEVICH, MOROZOV DMITRY VLADIMIROVICH
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to monoclonal humanized antibodies or antigen-binding fragments thereof that specifically bind to the TRBV9 family of human T cell receptors. The invention also relates to nucleic acids encoding said antibodies or antigen-binding fragments thereof, expression vectors, methods for preparing said antibodies and the use of said antibodies in the treatment of diseases or disorders associated with said family of human T cell receptors. The present invention relates to the production of antibodies which can be used in the treatment of, inter alia, ankylosing spondylitis (AS or Mellshortcut's disease), celiac disease and hematological cancers, whose pathogenesis relates to T cell receptors of the TRBV9 family. 本发明涉及特异性地结合人T细胞受体的TRBV9家族的单克隆人源化抗体或其抗原结合片段。本发明也涉及编码所述抗体或其抗原结合片段的核酸、表达载体、用于制备所述抗体的方法和所述抗体在治疗与人T细胞受体的所述家族有关的疾病或障碍中的用途。本发明涉及产生抗体，所述抗体可以用于治疗尤其是强直性脊柱炎(AS或别赫捷列夫氏病)、乳糜泻和血液癌症，其发病机制涉及TRBV9家族的T细胞受体。