Evodiamine compound as well as preparation method and application thereof
The invention belongs to the technical field of biological medicines, and particularly relates to an evodiamine compound as well as a preparation method and application thereof. Experiments prove that the evodiamine compound provided by the invention has a remarkable selective inhibition effect on P...
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| creator | LUO HAIBIN WU DEYAN YUAN SUYING HUANG YIYOU |
| description | The invention belongs to the technical field of biological medicines, and particularly relates to an evodiamine compound as well as a preparation method and application thereof. Experiments prove that the evodiamine compound provided by the invention has a remarkable selective inhibition effect on PDE5; moreover, the evodiamine compound has good drug-like properties such as half-life period, water solubility, stability and the like, and is very suitable for being applied to preparation of drugs for treating PDE5 related diseases.
本发明属于生物医药技术领域，具体涉及一种吴茱萸碱类化合物及其制备方法和用途。经过实验证明，本发明提供的吴茱萸碱类化合物对PDE5具有显著的选择性抑制作用；并且，本发明吴茱萸碱类化合物具有较好的半衰期、水溶性、稳定性等类药性质，非常合适应用于制备治疗PDE5相关疾病的药物。 |
| format | Patent |
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本发明属于生物医药技术领域，具体涉及一种吴茱萸碱类化合物及其制备方法和用途。经过实验证明，本发明提供的吴茱萸碱类化合物对PDE5具有显著的选择性抑制作用；并且，本发明吴茱萸碱类化合物具有较好的半衰期、水溶性、稳定性等类药性质，非常合适应用于制备治疗PDE5相关疾病的药物。</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220304&DB=EPODOC&CC=CN&NR=114133397A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220304&DB=EPODOC&CC=CN&NR=114133397A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LUO HAIBIN</creatorcontrib><creatorcontrib>WU DEYAN</creatorcontrib><creatorcontrib>YUAN SUYING</creatorcontrib><creatorcontrib>HUANG YIYOU</creatorcontrib><title>Evodiamine compound as well as preparation method and application thereof</title><description>The invention belongs to the technical field of biological medicines, and particularly relates to an evodiamine compound as well as a preparation method and application thereof. Experiments prove that the evodiamine compound provided by the invention has a remarkable selective inhibition effect on PDE5; moreover, the evodiamine compound has good drug-like properties such as half-life period, water solubility, stability and the like, and is very suitable for being applied to preparation of drugs for treating PDE5 related diseases.
本发明属于生物医药技术领域，具体涉及一种吴茱萸碱类化合物及其制备方法和用途。经过实验证明，本发明提供的吴茱萸碱类化合物对PDE5具有显著的选择性抑制作用；并且，本发明吴茱萸碱类化合物具有较好的半衰期、水溶性、稳定性等类药性质，非常合适应用于制备治疗PDE5相关疾病的药物。</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPB0LctPyUzMzcxLVUjOzy3IL81LUUgsVihPzckB0QVFqQWJRYklmfl5CrmpJRn5QFmQioKCnMxkiHBJRmpRan4aDwNrWmJOcSovlOZmUHRzDXH20E0tyI9PLS5ITE7NSy2Jd_YzNDQxNDY2tjR3NCZGDQD9cTTs</recordid><startdate>20220304</startdate><enddate>20220304</enddate><creator>LUO HAIBIN</creator><creator>WU DEYAN</creator><creator>YUAN SUYING</creator><creator>HUANG YIYOU</creator><scope>EVB</scope></search><sort><creationdate>20220304</creationdate><title>Evodiamine compound as well as preparation method and application thereof</title><author>LUO HAIBIN ; WU DEYAN ; YUAN SUYING ; HUANG YIYOU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN114133397A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LUO HAIBIN</creatorcontrib><creatorcontrib>WU DEYAN</creatorcontrib><creatorcontrib>YUAN SUYING</creatorcontrib><creatorcontrib>HUANG YIYOU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LUO HAIBIN</au><au>WU DEYAN</au><au>YUAN SUYING</au><au>HUANG YIYOU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Evodiamine compound as well as preparation method and application thereof</title><date>2022-03-04</date><risdate>2022</risdate><abstract>The invention belongs to the technical field of biological medicines, and particularly relates to an evodiamine compound as well as a preparation method and application thereof. Experiments prove that the evodiamine compound provided by the invention has a remarkable selective inhibition effect on PDE5; moreover, the evodiamine compound has good drug-like properties such as half-life period, water solubility, stability and the like, and is very suitable for being applied to preparation of drugs for treating PDE5 related diseases.
本发明属于生物医药技术领域，具体涉及一种吴茱萸碱类化合物及其制备方法和用途。经过实验证明，本发明提供的吴茱萸碱类化合物对PDE5具有显著的选择性抑制作用；并且，本发明吴茱萸碱类化合物具有较好的半衰期、水溶性、稳定性等类药性质，非常合适应用于制备治疗PDE5相关疾病的药物。</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Evodiamine compound as well as preparation method and application thereof |
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