Evodiamine compound as well as preparation method and application thereof

The invention belongs to the technical field of biological medicines, and particularly relates to an evodiamine compound as well as a preparation method and application thereof. Experiments prove that the evodiamine compound provided by the invention has a remarkable selective inhibition effect on PDE5; moreover, the evodiamine compound has good drug-like properties such as half-life period, water solubility, stability and the like, and is very suitable for being applied to preparation of drugs for treating PDE5 related diseases. 本发明属于生物医药技术领域，具体涉及一种吴茱萸碱类化合物及其制备方法和用途。经过实验证明，本发明提供的吴茱萸碱类化合物对PDE5具有显著的选择性抑制作用；并且，本发明吴茱萸碱类化合物具有较好的半衰期、水溶性、稳定性等类药性质，非常合适应用于制备治疗PDE5相关疾病的药物。