Inhibition of dipeptide repeat proteins

Disclosed are methods for treating neurodegenerative disorders, such as ALS and FTD, by using an effective amount of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor to reduce cytotoxicity caused by the dipeptide repeat protein (DRP). 公开了用于通过使用有效量的I型蛋白质精氨酸甲基转移酶(I型PRMT)抑制剂来降低由二肽重复蛋...

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Hauptverfasser:	GILL ANNA, VIEIRA FERNANDO G, PREMASIRI ALAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are methods for treating neurodegenerative disorders, such as ALS and FTD, by using an effective amount of a Type I protein arginine methyltransferase (Type I PRMT) inhibitor to reduce cytotoxicity caused by the dipeptide repeat protein (DRP). 公开了用于通过使用有效量的I型蛋白质精氨酸甲基转移酶(I型PRMT)抑制剂来降低由二肽重复蛋白(DRP)引起的细胞毒性以治疗神经退行性病症例如ALS和FTD的方法。