Preparation method of gadotetrol

The invention provides a gadotetrol preparation process, which comprises the following steps: adding pure water into a gadotetrol crude product for dissolving, performing intermittent ultrasonic treatment by using a digital ultrasonic instrument, introducing inert gas while performing ultrasonic operation, slowly dropwise adding ethanol and/or isopropanol during the intermittent period, stopping ultrasonic treatment, continuing magnetic stirring for 1-2 hours, standing for devitrification, filtering, and monitoring the conductivity of filtrate, thereby obtaining the gadotetrol. And finally, freeze-drying to obtain a product with higher purity, improved relaxation rate and reduced renal toxicity. 本发明提供了一种钆特醇制备工艺，将钆特醇粗品加纯水溶解，使用数字超声仪进行间歇超声，超声操作的同时通入惰性气体，间歇期间缓慢滴加乙醇和/或异丙醇，停止超声后继续磁力搅拌1-2h，静置析晶，过滤并监测滤液电导率，最后通过冷冻干燥获得纯度较高弛豫率提高且肾毒性降低的产品。