Duloxetine delayed release pharmaceutical composition and preparation method thereof

The invention discloses a duloxetine delayed release pharmaceutical composition and a preparation method thereof, the pharmaceutical composition comprises a pill core containing duloxetine or a salt thereof and an enteric-coated layer coating the pill core, the enteric-coated layer comprises cellulose acetate trimellitate and a plasticizer, the plasticizer is glycerin or a glycerin mixture, and based on accidental discovery, the enteric-coated layer can be used for preparing the duloxetine delayed release pharmaceutical composition. The drug prepared by coating the inert pellet core of duloxetine or the salt thereof with an intestinal solution prepared from cellulose acetate trimellitate and a glycerol plasticizer is basically the same as an original grinding agent in dissolution performance, is excellent in performance and stable in dissolution, does not need to be neutralized by ammonia water in the preparation process of the intestinal solution, simplifies the drug forming process again, improves the stabi