Purification method and application of olaparib

The invention provides a purification method and an application of olaparib. An intermediate compound IV is prepared by adopting a one-pot method, the synthesis process and the purification method of the compound IV and the olaparib are optimized, and the purification method has the advantages of being simple and convenient to operate, short in process period, low in production cost, easy to industrially produce, controllable in quality, high in yield, high in purity and the like. 本发明提供了奥拉帕利的纯化方法及其应用，采用一锅法制备中间体化合物IV，并优化了化合物IV和奥拉帕利的合成工艺及纯化方法，具有操作简便、工艺周期短、生产成本低、易于工业化生产的、质量可控、收率高、纯度高等优势。