A TRUNCATED VON WILLEBRAND FACTOR (VWF) FOR INCREASING THE IN VITRO STABILITY OF COAGULATION FACTOR VIII

A TRUNCATED VON WILLEBRAND FACTOR (VWF) FOR INCREASING THE IN VITRO STABILITY OF COAGULATION FACTOR VIII

The present invention relates to the use of a polypeptide comprising a truncated von Willebrand Factor (VWF) for increasing the in vitro stability of coagulation factor VIII (FVIII) in a composition comprising said FVIII and said polypeptide, wherein the molar ratio of the polypeptide to the FVIII i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LIEBING UWE, METZNER HUBERT
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention relates to the use of a polypeptide comprising a truncated von Willebrand Factor (VWF) for increasing the in vitro stability of coagulation factor VIII (FVIII) in a composition comprising said FVIII and said polypeptide, wherein the molar ratio of the polypeptide to the FVIII in the composition is greater than 20. 本发明涉及包含截短的血管性血友病因子(VWF)的多肽用于增加凝血因子VIII(FVIII)在包含所述FVIII和所述多肽的组合物中的体外稳定性的用途，其中所述多肽与所述FVIII在组合物中的摩尔比大于20。