COMBINATION THERAPY FOR TREATING HEPATITIS B VIRUS INFECTION

Described are RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B Virus (HBV) used in combination with a capsid assembly modulator (CAM) and methods of administering same. The HBV RNAi agents and CAMs are administered in ratios to effectively inhibit HBV gene expression and t...

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Hauptverfasser:	BIERMER MICHAEL, BEUMONT-MAUVIEL MARIA GLORIA, SIMMEN KENNETH ALAN, KALMEIJER RONALD C M, LENZ OLIVER, SNOEYS JAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described are RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B Virus (HBV) used in combination with a capsid assembly modulator (CAM) and methods of administering same. The HBV RNAi agents and CAMs are administered in ratios to effectively inhibit HBV gene expression and to treat diseases and conditions associated with HBV infection. 描述的是与衣壳组装调节剂(CAM)组合使用的、用于抑制乙型肝炎病毒(HBV)表达的RNA干扰(RNAi)试剂及其施用方法。HBV RNAi试剂和CAM按比率施用，以有效抑制HBV基因表达并且治疗与HBV感染相关的疾病和状况。