SPRAY-DRIED FORMULATION OF A PYRIDAZINONE TRPC5 INHIBITOR

Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprising the same. The dosage forms described herein are useful in meth...

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Hauptverfasser:	CORSON DONALD, STUMPFIG THOMAS E, SMITHEY DANIEL T, KWONG ELIZABETH CHU, SCHLESINGER ERICA B
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed are spray-dried formulations of 4-chloro-5-(4-(4-fluoro-2-(trifluoromethyl)phenoxy)-5,8-dihydropyrido[3,4-d]pyrimidin-7(6H)-yl)pyridazin-3(2H)-one, methods and compositions for making the same, and solid dosage forms comprising the same. The dosage forms described herein are useful in methods of treating kidney diseases or neuropathies associated with diseases or conditions, and in methods of treating pain, anxiety, or depression. 本发明公开了4-氯-5-(4-(4-氟-2-(三氟甲基)苯氧基)-5,8-二氢吡啶并[3,4-d]嘧啶-7(6H)-基)哒嗪-3(2H)-酮的喷雾干燥制剂、用于制备其的方法和组合物、以及包含其的固体剂型。本文所述的剂型可用于治疗与疾病或病症相关联的肾脏疾病或肾病的方法以及治疗疼痛、焦虑症或抑郁症的方法中。