COMPOSITIONS AND METHODS FOR ASSESSING MACROPHAGE MEDIATED PATHOLOGY

Compositions and methods are disclosed for assessing macrophage involvement in the inflammation of one or more joints of a subject. In certain aspects, the disclosed method includes the steps of administering to the subject a composition comprising a mannosylated dextran construct with an imaging moiety conjugated thereto; acquiring one or more planar images of a first joint of the subject; defining a region of interest (ROI) comprising the first joint; defining a joint specific reference region (RR); determining a MARTAD value of the joint by assessing the ratio of average pixel intensity of the ROI to the average pixel intensity of the RR; and comparing the MARTAD of the first joint to a normal MARTAD value for a corresponding joint, and macrophage involvement is indicated by a joint specific MARTAD value that exceeds the normal MARTAD value by a predetermined threshold. 公开了用于评估受试者的一个或多个关节的炎症中的巨噬细胞参与的组合物和方法。在某些方面，公开的方法包括以下步骤：给受试者施用组合物，所述组合物包含具有与其缀合的成像部分的甘露糖基化的葡聚糖构建体；获取受试者的第一关节的一个或多个平面图像；定义包含所述第一关节的感兴趣区域(ROI