Method for producing IMP and GMP through anti-solvent cooling crystallization based on solvent spray oscillation

The invention discloses a method for producing IMP and GMP through anti-solvent cooling crystallization based on solvent spray oscillation, wherein the method comprises the steps: adding raw materials IMP and GMP into water in a crystallization kettle, heating and stirring until the raw materials are completely dissolved, and adjusting the pH value; dropwise adding an anti-solvent, adding a crystal growth crystal, and cooling; enabling the solvent water to form fan-shaped water mist through a spray head, spraying the fan-shaped water mist onto a raw material liquid level of the crystallization kettle, enabling the use amount of the solvent water for primary solvent spray oscillation to be 25%-50% of the total amount of the solvent, controlling the primary spray time to be 1-2 min, recovering stirring to the heating stirring speed, cooling, and forming primary solvent spray oscillation; repeating the solvent spray oscillation for 2-4 times; and cooling, filtering, washing and drying to obtain a crystal product