Application of auranofin in preparation of medicine for preventing, treating and/or relieving psoriasis
The invention provides application of auranofin in preparation of a medicine for preventing, treating and/or relieving psoriasis. Animal tests show that auranofin has the effect of relieving psoriasis, can improve erythema, scales and epidermis thickening of an imiquimod-induced psoriasis-like mouse...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention provides application of auranofin in preparation of a medicine for preventing, treating and/or relieving psoriasis. Animal tests show that auranofin has the effect of relieving psoriasis, can improve erythema, scales and epidermis thickening of an imiquimod-induced psoriasis-like mouse model, can reduce the spleen index of a psoriasis mouse, can reduce the mRNA expression level of VEGFA, HIF-1alpha and other genes in the skin of the psoriasis-like mouse, meanwhile, the expression of anti-inflammatory cytokines IL-4 and IL-10 mRNA (messenger Ribonucleic Acid) related to Th2/Treg is increased; and in addition, the auranofin can obviously reduce the expression level of mRNA such as Th1/Th17 related proinflammatory factors IFN-gamma, IL-17A and the like at the skin lesion of the psoriasis mouse model. The auranofin effectively relieves the symptoms of psoriasis mice and has the prospect of being developed into the psoriasis treatment medicine.
本发明提供了金诺芬在制备用于预防、治疗和/或减轻银屑病的药物中的应用。动物试验显示,金诺芬具有缓解银屑病的作用, |
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