Chiral thioether-phosphine compound and preparation method thereof

The invention discloses a chiral thioether-phosphine compound in the structural formula. In the formula I, R1 represents 4-methylphenyl, 4-bromophenyl, 2, 6-dimethylphenyl, 2-methylphenyl, 2-methoxyphenyl, 2-naphthyl, benzyl or tertiary butyl, and R2 represents phenyl or 1, 1'-dinaphthyl. The invention also discloses a preparation method of the chiral thioether-phosphine compound. The invention also discloses a catalyst and application thereof. According to the invention, a thioether-phosphine ligand library is constructed by thiophenol, chiral amine and phenol, and the prepared chiral thioether-phosphine compound can be used as a chiral ligand for a palladium-catalyzed asymmetric allyl alkylation reaction. 本发明公开了一种其结构式为式I，式I中，R1表示4-甲基苯基、4-溴苯基、2,6-二甲基苯基、2-甲基苯基、2-甲氧基苯基、2-萘基、苄基或叔丁基，R2表示苯基或1,1'-联萘基。本发明还公开了手性硫醚-膦化合物的制备方法。本发明还公开了催化剂及其用途。本发明通过硫酚、手性胺和酚构建硫醚-膦配体库，制备得到的手性硫醚-膦化合物可作为钯催化的不对称烯丙基烷基化反应的手性配体。