Preparation method of flubendazole

The invention discloses a preparation method of fluorobendazole, wherein the preparation method comprises the steps: carrying out catalytic hydrolysis on 4-fluoro-trichlorotoluene serving as a raw material through zinc chloride or ferric chloride to obtain p-fluorobenzoyl chloride; and carrying out Friedel-Crafts reaction on the p-fluorobenzoyl chloride, carbendazim (N-(2-benzimidazolyl)-methyl carbamate) dissolved in formic acid or acetic acid and anhydrous aluminum chloride to obtain the flubendazole. Compared with the prior art, the process has the advantages that the reaction process can be remarkably shortened, intermediate loss is reduced, high-pressure hydrogenation and ammoniation are not needed, the reaction conditions are relatively mild, the industrialization difficulty is low, and the process has strong development space and competitive capacity. 本发明公开了一种氟苯咪唑的制备方法，以4-氟-三氯甲苯为原料，通过氯化锌或氯化铁催化水解得到对氟苯甲酰氯，对氟苯甲酰氯再与溶解于甲酸或乙酸中的多菌灵(N－(2－苯并咪唑基)－氨基甲酸甲酯)、无水氯化铝进行傅克反应得到氟苯咪唑。本发明与现有技术相比，使用本工艺可以显著缩短反应流程，减少中间损失，无需经过高压