Preparation method of dinaverine hydrochloride

The invention relates to a preparation method of dinaverine hydrochloride, the methdo comprises the following steps: using 2, 2-diphenyl-2-glycolic acid as a raw material, adding reagents such as thionyl chloride and the like, reacting carboxyl in 2, 2-diphenyl-2-glycolic acid molecules to form acyl chloride and reacting benzyl alcohol to form benzyl chloride in one step; adding dimethylaminoethanol under certain conditions, reacting with acyl chloride to obtain ester, adding 2-ethyl butanol, controlling reaction conditions, and reacting with benzyl chloride to obtain denaverine hydrochloride; the reaction route solves the problems that the esterification solid-liquid reaction speed is low and high-temperature reaction is needed, the reaction condition is mild, the speed is high, and the yield is high. 本发明涉及一种盐酸地那维林的制备方法，该方法使用2,2-二苯基-2-羟基乙酸为原料，加入氯化亚砜等试剂，一步将2,2-二苯基-2-羟基乙酸分子中的羧基反应成酰氯，苄醇反应成苄氯；然后在一定的条件下，加入二甲氨基乙醇，与酰氯反应得到酯，然后加入2-乙基丁醇，控制反应条件，与苄氯反应得到盐酸地那维林；该反应路线解决了成酯固液反应速度慢且需要高温反应的问题，反应条件温和，且速度快，收率高。