Bone repair scaffold material capable of mediating nervalization and preparation method and application thereof

The invention discloses a bone repair scaffold material capable of mediating nervalization and a preparation method and application thereof. The preparation method comprises the steps that heterologous expression bone matrix fusion protein is adsorbed into calcium and magnesium doped mesoporous bioactive glass prepared through a sol-gel and template self-assembly method to serve as an inner core; nerve growth factors capable of promoting nerve growth are loaded into silk protein to serve as a shell, and then the bone repair scaffold material which is of a core-shell structure and can be used for mediating nervalization is prepared through a coaxial electrostatic spinning technology. The bone repair scaffold material capable of mediating the nervalization has good cell compatibility, osteogenic activity, neurogenic activity and calcium deposition promotion effects, can promote proliferation, differentiation and mineralization processes of bone marrow mesenchymal stem cells in the osteogenic direction, can also