Preparation method of bionic nano drug delivery system based on ginsenoside
The invention belongs to the field of nano drugs, and particularly relates to a preparation method of a bionic nano drug delivery system based on ginsenoside. According to the invention, nano-selenium with the effects of resisting oxidation and reducing blood fat is used as a drug carrier to deliver...
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Zusammenfassung: | The invention belongs to the field of nano drugs, and particularly relates to a preparation method of a bionic nano drug delivery system based on ginsenoside. According to the invention, nano-selenium with the effects of resisting oxidation and reducing blood fat is used as a drug carrier to deliver a drug ginsenoside with the effects of promoting lipid metabolism and resisting inflammation, and meanwhile, a bionic nano drug delivery system which is low in toxicity, good in biocompatibility and capable of targeting a focus part is prepared by the inherent plaque targeting capability of a platelet membrane. The system respectively retains the advantages of nano-drugs and platelet membranes, can significantly improve the drug concentration enrichment at atherosclerotic plaques, reduces toxic and side effects, and has wide potential clinical application prospects.
本发明属于纳米药物领域,具体涉及一种基于人参皂苷的仿生纳米递药系统的制备方法。本发明以具有抗氧化、降血脂作用的纳米硒为药物载体,递送具有促进脂质代谢和抗炎作用的药物人参皂苷,同时结合血小板膜固有的靶向斑块能力制备得到低毒、生物相容性好、可靶向病灶部位的仿生纳米递药系统,该体系分别保留了纳米药物和血小 |
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