Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound
The invention discloses a compound with PI3Kdelta/BTK double-target activity, a preparation method of the compound and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by PI3K delta or BTK protein abnormity. In particular, compound...
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| creator | CHANG XINYUE LIANG MEIHAO ZENG SHENXIN SHEN ZHENGRONG ZHANG CHIXIAO WANG ZUNYUAN HUANG WENHAI |
| description | The invention discloses a compound with PI3Kdelta/BTK double-target activity, a preparation method of the compound and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by PI3K delta or BTK protein abnormity. In particular, compounds of Formula A are described. The main advantage of combined application of the two inhibitors is that the treatment effect of "1+1>2" can be realized through complementary synergistic effect, and the double-target inhibitor not only can ensure the treatment effect of the medicine, but also can reduce the risk of medicine-medicine interaction by reducing the administration dosage, so that the safety can be further improved; therefore, the compound with PI3K delta/BTK double-target activity provided by the invention can be widely applied to preparation of pharmaceutical preparations for preventing or treating diseases caused by B cell receptor abnormality.
本发明公开了一种具有PI3Kδ/BTK双靶点活性的化合物及其制备方法和在制备预防或治疗因PI3Kδ或BTK蛋白异常所引起 |
| format | Patent |
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本发明公开了一种具有PI3Kδ/BTK双靶点活性的化合物及其制备方法和在制备预防或治疗因PI3Kδ或BTK蛋白异常所引起</description><language>chi ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220125&DB=EPODOC&CC=CN&NR=113968861A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220125&DB=EPODOC&CC=CN&NR=113968861A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHANG XINYUE</creatorcontrib><creatorcontrib>LIANG MEIHAO</creatorcontrib><creatorcontrib>ZENG SHENXIN</creatorcontrib><creatorcontrib>SHEN ZHENGRONG</creatorcontrib><creatorcontrib>ZHANG CHIXIAO</creatorcontrib><creatorcontrib>WANG ZUNYUAN</creatorcontrib><creatorcontrib>HUANG WENHAI</creatorcontrib><title>Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound</title><description>The invention discloses a compound with PI3Kdelta/BTK double-target activity, a preparation method of the compound and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by PI3K delta or BTK protein abnormity. In particular, compounds of Formula A are described. The main advantage of combined application of the two inhibitors is that the treatment effect of "1+1>2" can be realized through complementary synergistic effect, and the double-target inhibitor not only can ensure the treatment effect of the medicine, but also can reduce the risk of medicine-medicine interaction by reducing the administration dosage, so that the safety can be further improved; therefore, the compound with PI3K delta/BTK double-target activity provided by the invention can be widely applied to preparation of pharmaceutical preparations for preventing or treating diseases caused by B cell receptor abnormality.
本发明公开了一种具有PI3Kδ/BTK双靶点活性的化合物及其制备方法和在制备预防或治疗因PI3Kδ或BTK蛋白异常所引起</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjcEKglAQRd20iOofpg-QEEFsaVIUQrRwL9N7Yz54OoOOSX9fkR_Q6sDlcM8ykJxb4bGzMDlt4HaJC0tecXcoC7A83j2Fiv2DFNCoezp9AQ4wkfdfSk-CParjDlrShi3g5wtFvDO_mWvQhsDMnXWwqNEPtJm5CranY5mfQxKuaBA01JFW-TWK4n2SpkmUxf84b9myQr8</recordid><startdate>20220125</startdate><enddate>20220125</enddate><creator>CHANG XINYUE</creator><creator>LIANG MEIHAO</creator><creator>ZENG SHENXIN</creator><creator>SHEN ZHENGRONG</creator><creator>ZHANG CHIXIAO</creator><creator>WANG ZUNYUAN</creator><creator>HUANG WENHAI</creator><scope>EVB</scope></search><sort><creationdate>20220125</creationdate><title>Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound</title><author>CHANG XINYUE ; LIANG MEIHAO ; ZENG SHENXIN ; SHEN ZHENGRONG ; ZHANG CHIXIAO ; WANG ZUNYUAN ; HUANG WENHAI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN113968861A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CHANG XINYUE</creatorcontrib><creatorcontrib>LIANG MEIHAO</creatorcontrib><creatorcontrib>ZENG SHENXIN</creatorcontrib><creatorcontrib>SHEN ZHENGRONG</creatorcontrib><creatorcontrib>ZHANG CHIXIAO</creatorcontrib><creatorcontrib>WANG ZUNYUAN</creatorcontrib><creatorcontrib>HUANG WENHAI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHANG XINYUE</au><au>LIANG MEIHAO</au><au>ZENG SHENXIN</au><au>SHEN ZHENGRONG</au><au>ZHANG CHIXIAO</au><au>WANG ZUNYUAN</au><au>HUANG WENHAI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound</title><date>2022-01-25</date><risdate>2022</risdate><abstract>The invention discloses a compound with PI3Kdelta/BTK double-target activity, a preparation method of the compound and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by PI3K delta or BTK protein abnormity. In particular, compounds of Formula A are described. The main advantage of combined application of the two inhibitors is that the treatment effect of "1+1>2" can be realized through complementary synergistic effect, and the double-target inhibitor not only can ensure the treatment effect of the medicine, but also can reduce the risk of medicine-medicine interaction by reducing the administration dosage, so that the safety can be further improved; therefore, the compound with PI3K delta/BTK double-target activity provided by the invention can be widely applied to preparation of pharmaceutical preparations for preventing or treating diseases caused by B cell receptor abnormality.
本发明公开了一种具有PI3Kδ/BTK双靶点活性的化合物及其制备方法和在制备预防或治疗因PI3Kδ或BTK蛋白异常所引起</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound |
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