Compound with PI3Kdelta/BTK double-target activity as well as preparation method and application of the compound

The invention discloses a compound with PI3Kdelta/BTK double-target activity, a preparation method of the compound and application of the compound in preparation of a pharmaceutical preparation for preventing or treating diseases caused by PI3K delta or BTK protein abnormity. In particular, compounds of Formula A are described. The main advantage of combined application of the two inhibitors is that the treatment effect of "1+1>2" can be realized through complementary synergistic effect, and the double-target inhibitor not only can ensure the treatment effect of the medicine, but also can reduce the risk of medicine-medicine interaction by reducing the administration dosage, so that the safety can be further improved; therefore, the compound with PI3K delta/BTK double-target activity provided by the invention can be widely applied to preparation of pharmaceutical preparations for preventing or treating diseases caused by B cell receptor abnormality. 本发明公开了一种具有PI3Kδ/BTK双靶点活性的化合物及其制备方法和在制备预防或治疗因PI3Kδ或BTK蛋白异常所引起