BISPECIFIC ANTIBODY AGAINST [alpha]-SYN/IGF1R AND USE THEREOF

The present specification relates to a bispecific antibody that specifically binds to [alpha]-synuclein and IGF1R, and to a use of the bispecific antibody in preventing, treating and/or diagnosing synucleinopathy, which is a disease associated with [alpha]-synuclein or aggregates thereof. The bispecific antibody enables an [alpha]-syn antibody or an antigen-binding fragment thereof to pass through the blood-brain barrier and exert an action of the antibody or the fragment in the brain, and extends the half-life thereof, thereby allowing drug efficacy to sustain for a long time. 本公开涉及与α-突触核蛋白和IGF1R特异性结合的双特异性抗体，以及该双特异性抗体在预防、治疗和/或诊断α-突触核蛋白病中的用途，α-突触核蛋白病是与α-突触核蛋白或α-突触核蛋白聚集体相关的疾病。双特异性抗体使得α-syn抗体或其抗原结合片段能够穿透血脑屏障并在脑中发挥抗体或片段的作用，并延长半衰期，从而允许长时间维持药物功效。